MeDIP-seq

How it works

MeDIP-seq combines methylated DNA immunoprecipitation with sequencing to identify regions enriched for DNA methylation. It provides a regional view of methylation patterns for comparisons across samples and the identification of regions for further investigation.

Applications

• Compare methylation-enriched regions across tissues or treatments
• Investigate methylation patterns associated with disease onset and progression
• Use genomic annotation to prioritize genes associated with enriched regions

Key features

• Antibody-based enrichment of methylated DNA fragments
• Regional methylation profiling for comparative studies
• Enrichment readouts at the genomic-region level

Workflow

1. 01

   Extract DNA and assess sample quality

2. 02

   Fragment DNA and immunoprecipitate methylated fragments

3. 03

   Prepare libraries and sequence

4. 04

   Identify enriched regions and compare methylation signals

We tailor the experimental workflow and analysis to your samples and study objectives.