Whole-Genome Sequencing (WGS)

How it works

Whole-genome sequencing provides sequence information across coding and noncoding regions for the study of inherited and somatic variation. We tailor the reference genome, sequencing depth and variant analysis to your species, samples and research question.

Applications

• Investigate genetic differences between individuals and prioritize variants for follow-up
• Compare somatic variants across tissues or study groups
• Study genetic variation in cancer, inherited disease and populations

Key features

• Broad coverage of coding and noncoding regions
• Analysis options for SNPs, indels, copy-number variants and structural variants
• Sequencing depth and analysis designed around sample quality and the variants of interest

Workflow

1. 01

   Extract DNA and assess sample quality

2. 02

   Prepare whole-genome sequencing libraries

3. 03

   Sequence libraries and assess alignment and coverage

4. 04

   Call, annotate and prioritize variants

We tailor the experimental workflow and analysis to your samples and study objectives.