The Research Question
This client study examines how NSD2 regulates erastin-induced ferroptosis in keratinocytes.
Combining Transcriptomic and Epigenomic Data
RNA-seq measures changes in gene expression, while CUT&Tag profiles H3K36me2-associated signals. Bringing these datasets together allows researchers to investigate the relationship between transcriptional changes and epigenetic regulation.
Following Up with Functional Experiments
The researchers examined candidate genes including NCOA4, LPCAT3 and ATG5 in subsequent functional experiments, connecting findings from omics analysis with experimental testing.
Publication
NSD2 is a critical regulator of Erastin-induced ferroptosis in keratinocytes
Free Radical Biology and Medicine
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